We aim to understand the molecular basis of gene regulation specificity in Drosophila using genetics, genomics, biochemistry and live-imaging tools.
In multicellular organisms, genes are turned ON and OFF in robust spatial and temporal patterns. Regulatory elements that activate or silence gene transcription are inherently promiscuous and can act over long genomic distances. A basic question is how regulatory elements find their target promoters and restrict their activity to their targets.
On the one hand, we study how regulatory crosstalk is prevented. Insulators were discovered in Drosophila and subsequently in various organisms from yeast to humans, as DNA elements that block communication between a regulatory element and a gene promoter when placed in between. In flies and humans, insulators exert their activity by recruiting insulator proteins. We study the biological relevance and molecular mechanisms of insulator proteins.
On the other hand, we study how genes find their appropriate regulatory elements across surprisingly long genomic distances and skip over non-target genes. We address the biological relevance of these interactions by disrupting them, and we study how they form.
Our studies in flies reveal new evolutionary perspectives into the relevance of 3D genome folding for correctly wiring genes to their regulatory elements.
Anjali Kaushal, Julien Dorier, Bihan Wang, Giriram Mohana, Michael Taschner, Pascal Cousin, Patrice Waridel, Christian Iseli, Anastasiia Semenova, Simon Restrepo, Nicolas Guex, Erez Lieberman Aiden & Maria Cristina Gambetta
Science Advances 2022 · DOI / WOSUID
C. Hoencamp, O. Dudchenko, A.M.O. Elbatsh, S. Brahmachari, J.A. Raaijmakers, T. van Schaik, A.S. Cacciatore, V.G. Contessoto, R.G.H.P. van Heesbeen, B. van den Broek, A.N. Mhaskar, H. Teunissen, B.G. St Hilaire, D. Weisz, A.D. Omer, M. Pham, Z. Colaric, Z.Z. Yang, S.S.P. Rao, N. Mitra, C. Lui, W.J. Yao, R. Khan, L.L. Moroz, A. Kohn, J. St Leger, A. Mena, K. Holcroft, Maria Cristina Gambetta, F.B.A. Lim, E. Farley, N. Stein, A. Haddad, D. Chauss, A.S. Mutlu, M.C. Wang, N.D. Young, E. Hildebrandt, H.H. Cheng, C.J. Knight, T.L.U. Burnham, K.A. Hovel, A.J. Beel, P.J. Mattei, R.D. Kornberg, W.C. Warren, G. Cary, J.L. Gomez-Skarmeta, V. Hinman, K. Lindblad-Toh, F. Di Palma, K. Maeshima, A.S. Multani, Sen Pathak, L. Nel-Themaat, R.R. Behringer, P. Kaur, R.H. Medema, B. van Steensel, E. de Wit, J.N. Onuchic, M. Di Pierro, E.L. Aiden & B.D. Rowland
Anjali Kaushal, Giriram Mohana, Julien Dorier, Isa Özdemir, Arina Omer, Pascal Cousin, Anastasiia Semenova, Michael Taschner, Oleksandr Dergai, Flavia Marzetta, Christian Iseli, Yossi Eliaz, David Weisz, Muhammad Saad Shamim, Nicolas Guex, Erez Lieberman Aiden & Maria Cristina Gambetta
Nature Communications 2021 · DOI / WOSUID
Isa Özdemir & Maria Cristina Gambetta
Maria Cristina Gambetta & Eileen E M Furlong
Genetics 2018 · PMID / PMC / DOI
Maria Cristina Gambetta & Jürg Müller
Chromosoma 2015 · PMID / PMC / DOI
Maria Cristina Gambetta & Jürg Müller
Developmental cell 2014 · PMID / DOI
Claudio Alfieri, Maria Cristina Gambetta, Raquel Matos, Sebastian Glatt, Peter Sehr, Sven Fraterman, Matthias Wilm, Jürg Müller & Christoph W. Müller
Genes & development 2013 · PMID / PMC / DOI
Luis Gutiérrez, Katarzyna Oktaba, Johanna C. Scheuermann, Maria Cristina Gambetta, Nga Ly-Hartig & Jürg Müller
Maria Cristina Gambetta, Katarzyna Oktaba & Jürg Müller
Science (New York, N.Y.) 2009 · PMID / DOI
|2018-current||Tenure-track assistant professor||Center for Integrative Genomics, University of Lausanne, Switzerland|
|2015-2017||Postdoctoral researcher||European Molecular Biology Laboratory (EMBL) Heidelberg, Germany|
|2010-2015||Postdoctoral researcher||Max Planck Institute of Biochemistry in Martinsried, Germany|
|2006-2010||PhD in Biology||European Molecular Biology Laboratory (EMBL) Heidelberg, Germany|
|2004-2006||M.Sc. Biology||University of Geneva, Switzerland|
|2001-2004||B.Sc. Biology||University of Geneva, Switzerland|
|2005 - present||Technician||Center for Integrative Genomics, University of Lausanne, Switzerland|
|2017 - 2019||M.Sc. Biology||Taras Shevchenko National University of Kyiv, ESC Institute of Biology and Medicine, Kyiv, Ukraine|
|2013 - 2017||B.Sc. Biology||Taras Shevchenko National University of Kyiv, ESC Institute of Biology and Medicine, Kyiv, Ukraine|
|2017 - 2018||M.Sc. Biochemistry||University of Florida, USA|
|2010 - 2014||B.Sc.||Wuhan University, School of Pharmaceutical Science, China|
|2018 - 2020||M.Sc. Cellular and Molecular Biology||Lyon 1 University, France|
|2016 - 2018||Assistant engineer||École Normale Supérieure of Lyon (ENSL), France|
|2015 - 2016||B.Sc. Biotechnology speciality Genomics||Lyon 1 University, France|
|2013 - 2015||Technical degree in Biotechnology||Martinière Duchère high school, France|
|2019 - 2021||Project Assistant||National Chemical Laboratory, India|
|2014 - 2019||M.Sc.||Institute of Bioinformatics and Biotechnology, Savitribai Phule Pune University, India|
|2020 - 2022||Research Intern||Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany|
|2018 - 2021||M.Sc. in Molecular Life Sciences||Friedrich-Schiller-Universität Jena, Jena, Germany|
|2013 - 2017||B.Sc. in Biotechnology||Purbanchal University, Kathmandu, Nepal|
|2021-present||Laboratory technician apprentice||University of Lausanne, Switzerland|
|Giriram Mohana||Postdoc||Scientific Officer||Cellzome Heidelberg|
|Anjali Kaushal||PhD student||NGS scientist||Sophia genetics|
|Daniel Rodriguez||M. Sc.||PhD student||FMI Basel|
|Tasniem Fetian||Intern||PhD student||University of Pittsburgh|
|Héléna Malek||M. Sc.||M. Sc||INSERM Paris|
Prof. Maria Cristina Gambetta
Center for Integrative Genomics (CIG)
University of Lausanne
mariacristina.gambetta [at] unil.ch
Office: Room 3030
Phone: +41 21 692 3985
Are you interested in investigating basic mechanisms of gene regulation specificity?
We are looking for talented and enthusiastic team members at any level with a background in molecular biology, genetics, genomics or imaging. You are eager to engage in scientific discussions, capable of working in a team as well as independently.
Our lab is hosted at the Center for Integrative Genomics (CIG) at the University of Lausanne (UNIL), a vibrant, well-funded institute with a focus on functional genomics and equipped with modern core facilities. We are embedded in the broader Lausanne research environment that includes two universities (UNIL, EPFL), the Swiss Institute of Bioinformatics, Ludwig Center for Cancer Research, University Hospital, and a cluster of biotech companies flourishing in the larger lake Geneva area. We tightly network with other gene regulation labs at UNIL and EPFL, and collaborate with the on-site Bioinformatics Competence Center. There are regular possibilities to present and participate in local or international conferences and workshops. Hard and soft skill, and career development courses are offered on campus. We offer a nice working place in a multicultural, diversified and dynamic academic environment. PhD students will enroll in the UNIL Doctoral Program in Quantitative Biology.
Spontaneous applications are welcome anytime for Master’s/PhD/postdoc fellowships, while fully-funded positions are advertised below.
! We are currently hiring postdoctoral fellows !
To apply or request more information, email mariacristina.gambetta [at] unil.ch. Provide your CV, a brief description of your research experience, and why you think your research interests complement ours.
We encourage applications from candidates who will contribute to our team’s diversity.